| Robert Seiler: | WNCW volunteer, Purple Onion music booker | 1/5/22 |
| Michael Lang: | co-creator: Woodstock Music & Arts Festival | 1/8/22 |
| Ronnie Spector: | singer: The Ronettes | 1/12/22 |
| Rachel Nagy: | singer: Detroit Cobras | 1/15/22 |
| Meat Loaf: | singer, actor | 1/20/22 |
| Don Wilson: | guitarist: co-founder of The Ventures | 1/22/22 |
| Sam Lay: | drummer: Howlin' Wolf, John Lee Hooker, Paul Butterfield, Bo Diddley, Muddy Waters, others. | 1/29/22 |
| Norma Waterson: | singer/songwriter | 1/30/22 |
| Donny Gerrard: | singer: Mavis Staples, Skylark | 2/3/22 |
| Don Humphries: | songwriter, singer, guitarist | 2/4/22 |
| Gary Brooker: | singer, songwriter: Procol Harum | 2/19/22 |
| Mark Lanegan: | singer: Screaming Trees, Queens of the Stone Age, Gutter Twins | 2/22/22 |
| Jimmy Landry: | singer/songwriter, from Black Mountain | 2/22/22 |
| Chris Garges: | drummer, producer, engineer, from Charlotte | 2/22/22 |
| Bobbie Nelson: | pianist | 3/10/22 |
| Jim Miller: | singer, guitarist: Western Centuries, Donna the Buffalo | 3/24/22 |
| Roland White: | multi-instrumentalist, singer | 4/1/22 |
| Judy Henske: | singer, comedian | 4/27/22 |
| Mickey Gilley: | singer, songwriter | 5/7/22 |
| Alan White: | drummer: Yes | 5/26/22 |
| Andy Fletcher: | keyboardist: Depeche Mode | 5/26/22 |
| Ronnie Hawkins: | singer, band leader: The Hawks | 5/29/22 |
| Kelly Joe Phelps: | singer, songwriter, guitarist | 5/31/22 |
| Deborah McCrary: | singer, founder of The McCrary Sisters | 6/1/22 |
| Jim Seals: | singer, songwriter | 6/6/22 |
| Julee Cruise: | singer | 6/9/22 |
| Dennis Cahill: | guitarist, from Ireland | 6/20/22 |
| Mick Moloney: | musician, folklorist of Irish-American culture | 7/27/22 |
| Olivia Newton-John: | singer, actor, activist | 8/8/22 |
| Jerry Allison | drummer: Buddy Holly & the Crickets, Waylon Jennings | 8/22/22 |
| Creed Taylor: | producer, label founder: bossa nova and jazz artists; Impulse Records, CTI Records | 8/22/22 |
| Mable John: | singer: Motown, Stax | 8/25/22 |
| Art Rosenbaum: | musician, folklorist, painter | 9/4/22 |
| Wes Freed: | artist: designed all of the Drive-By Truckers albums | 9/4/22 |
| Ray Edenton: | guitarist: the "A-team" of Nashville musicians, on over 12,000 studio sessions, including Roger Miller & Webb Pierce | 9/21/22 |
| Pharoah Sanders: | saxophonist | 9/24/22 |
| Joe Bussard: | record collector, radio host | 9/26/22 |
| Debra Clifford: | singer, guitarist: The Lonesome Sisters, Old Buck | 9/27/22 |
| Mary McCaslin: | singer, guitarist, banjoist | 10/2/22 |
| Loretta Lynn: | singer, songwriter, coal miner's daughter | 10/4/22 |
| Anita Kerr: | singer: Anita Kerr Singers, a.k.a. "Little Miss Nobody" | 10/10/22 |
| Jerry Lee Lewis: | singer, piano player, Killer | 10/28/22 |
| Mimi Parker: | singer, drummer: Low | 11/5/22 |
| Gal Costa: | singer, from Bahia, Brazil | 11/9/22 |
| Christine McVie: | singer, songwriter, keyboardist: Fleetwood Mac | 11/30/22 |
| Peter Cooper: | singer, songwriter, musician, journalist, historian | 12/6/22 |
| Herbert Deutsch: | keyboardist, co-inventor of the Moog synthesizer | 12/9/22 |
| Terry Hall: | singer: The Specials | 12/18/22 |
| Walter "Wolfman" Washington: | singer, guitarist | 12/22/22 |
